septin M |
sequence motif |
MFG-E8-derived short peptide 68 |
||
[septoclast]
This cell type has been described by Lee et al (2005). Septoclasts are specialized, perivascular cells that facilitate capillary invasion of the chondro-osseous junction. They play a role in the erosion of uncalcified transverse septa at the transition between growth plate cartilage and the endochondral bone region, to allow the advance of invasive capillaries. Septoclasts are packed with multivesicular and dense bodies rich in the protease cathepsin B.
The cells are located such that the cell body and nucleus lie just behind the budding end of the capillary. Their cytoplasm extends toward the growth plate and takes on a ruffled border-like appearance adjacent to the terminal transverse septum of the growth plate. There are also signs of a dissociated extracellular matrix. The cells
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