SECRET domain containing protein 3 |
secretase |
z13 |
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approved gene symbol: SCGN; abbr. also SEGN; databank synonym also: SECRET. The gene encoding this protein has been cloned by Wagner et al (2000). Secretagogin is a calcium-binding protein expressed in human pancreatic beta-cells and thyroid C-cells, as well as epithelial cells in the stomach, small intestine, and colonic crypts. The protein has an antiproliferative effect on RIN-5F insulinoma cells. It downregulates expression of substance P in these cells.
Zierhut et al (2005) have reported a variant of secretagogin, termed Setagin
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