sag

[sensitive to apoptosis gene] This gene is known also as ROC-2, Rbx-2, Hrt-2, and CKBBP1 [CKII beta-binding protein 1; casein kinase 2-beta binding protein 1]. It has been identified originally as a zinc RING finger protein that protects cells from cell death by apoptosis induced by redox agents (Duan et al, 1999). sag is a component of SCF-E3 Ubiquitin Ligase, which controls cell cycle progression by promoting ubiquitination and degradation of cell cycle inhibitors (Swaroop et al, 2001). The human gene has been mapped to chromosome 3q22-24. sag is an ... ... ... ...
 
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Entry last modified: August 2021