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receptor inducing factor

abbr. RIF (a term with multiple meanings). This biochemically uncharacterized glycoprotein of approximately 44 kDa is produced by murine P388-D1 cells (derived from macrophages). Glycosylation is not required for the biological activity of this factor.

This receptor inducing factor functions as a costimulator of IL2 receptor expression in resting CD8(+) T-cells and activated via the CD3 T-cell receptor. The factor is a competence factor (see: cell activation) that bestows upon cells the ability to respond to IL2. See also: IL2 receptor inducing factor.

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Entry last modified: August 2005

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