Pancreatic lysophospholipase |
pancreatic polypeptide cells |
alpha-IB-92-(66-92) |
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abbr. PP, PPY; approved gene symbol: PNP. Pancreatic polypeptide (APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYamide) is a hormone produced by endocrine cells (see: PP cells) of the duodenal pancreas (Kimmel et al, 1975; Larsson et al, 1976). Pancreatic polypeptide is synthesized as the N-terminal part of a relatively small precursor (95 amino acids) (Schwartz and Tager, 1981; Leiter et al, 1984, 1985; Takeuchi et al, 1986). Pancreatic polypeptide and neuropeptide Y (NPY) show over 50 % homology of amino acid and nucleotide sequence. The precursor also contains the sequence of another peptide of unknown function (see: pancreatic icosapeptide),
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