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neuroendocrine differentiation factor

abbr. NEDF. This protein has been identified by Wilson et al (2001), who also refer to it as 25.1. The protein has a nuclear location and interacts with an IGF binding protein. Transient expression of the factor in a stable prostate cancer cell line overexpressing IGFBPRP1 [IGF-binding protein-related protein 1] causes the emergence of long dendritic-like processes and the expression of the neuroendocrine markers chromogranin A and neuron-specific enolase, suggesting that the protein can induce neuroendocrine cell differentiation in prostate cancer cells.

The approved gene symbol is CHMP3 [CHMP family member 3; ... ... ... ... ... Subscribe to continue reading! ... ...

 

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