mitoptosis

This term has been used to describe a form of cell death associated with dysfunctional mitrochondria. SOme authors have used the term mitochondrial suicide. Mitoptosis is mediated by reactive oxygen species, which cause the opening of the permeability transition pores in the inner mitochondrial membrane (see also: Venditti et al, 2013). Massive mitoptosis can cause cell death due to the release into the cytosol of cell death proteins normally hidden within mitochondrial intermembrane spaces (Skulachev, 2006).

Lyamzaev KG et al (2008) have reported that mitoptosis is induced by uncoupling of oxidative phosphorylation and is a mechanism serving to eliminate malfunctioning mitochondria rather than a distinct mode of regulated cell death ... ... ... ...
 
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Entry last modified: March 2024