macrocytes

This is a general term for erythrocytes with a size that is noticeably larger than those of normal erythrocytes (Pribush et al, 1995; Coopersmith and Ingram, 1969) (see also: discocytes). A discrimination between normally and abnormally sized may be difficult (Haun et al, 2002). Hypochromic macrocytes are large cells with a reduced hemoglobin content.

Most commonly increased numbers of such enlarged cells are caused by vitamin B12 or folate deficiency, liver disease, and reticulocytosis (Ward, 1979). Increased numbers of such cells often indicate an increased reticulocyte count (Bain and Cavill, 1993). Macrocytes are observed also in some forms of ... ... ... ...
 
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Entry last modified: October 2006