leukoblasts |
Leukocystatin |
out of bounds |
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This octapeptide, GKVLKKRR (Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg) corresponds to the ACTH like amino acids 81-88 of human pro-interleukin-1-alpha (pro-interleukin-1-alpha(81-88); proIL1-alpha(81-88)). It is not known whether the peptide is generated from IL1-alpha in vivo and might constitute a bioactive cryptide (see also: Immunocortin [ACTH-like Peptide].
The peptide specifically interacts with one type of receptor on the surface of murine splenocytes and with two types of receptors on the surface of murine peritoneal macrophages. The
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