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leukocorticotropin

This octapeptide, GKVLKKRR (Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg) corresponds to the ACTH like amino acids 81-88 of human pro-interleukin-1-alpha (pro-interleukin-1-alpha(81-88); proIL1-alpha(81-88)). It is not known whether the peptide is generated from IL1-alpha in vivo and might constitute a bioactive cryptide (see also: Immunocortin [ACTH-like Peptide].

The peptide specifically interacts with one type of receptor on the surface of murine splenocytes and with two types of receptors on the surface of murine peritoneal macrophages. The ... ... ... ... ... Subscribe to continue reading! ... ...

 

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