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keratolinin

This protein has been identified in keratinocytes as a substrate of human and bovine epidermal transglutaminase (glutaminyl-peptide gamma-glutamyltransferase, R-glutaminyl-peptide:amine-gamma-glutamyltransferase, EC 2.3.2.13). Keratolinin is ultimately polymerized on the inner leaflet of the keratinocyte membrane to form the cornified envelope (Zettergren et al, 1984).

Sequence analysis of the cloned cDNA shows that the protein is identical with Cystatin A (Takahashi et al, 1997).

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