jeb
[jelly belly] jeb, encoded by gene CG30040, is a secreted protein that contains an LDL receptor repeat. jeb is required for visceral mesoderm development. In jeb mutants, visceral mesoderm precursors are formed but fail to migrate or differentiate normally so that no visceral muscles develop (Weiss et al, 2001).
The Jeb receptor, encoded by CG8250, has been identified as the Drosophila homolog of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) (Lee et al, 2003; Englund et al, 2003). Activation of the receptor by jeb induces the myoblast fusion gene dumbfounded (also known as
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