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The chromosomal inv gene of Yersinia pseudotuberculosis [Yersinia pseudotuberculosis invasin] encodes an outer membrane protein of 986 amino acid that has been termed Invasin (Isberg et al, 1987; Isberg and Falkow, 1985). Note that this term is used also in a more general sense for pathogen-derived proteins facilitating pathogen entry into cells.


The inv gene product is the most important and essential virulence factor in enteropathogenic Yersinia, being responsible for bacterial adherence and penetration within epithelial cells of the intestinal lumen and for the subsequent colonization of regional lymph nodes. Yersinia pseudotuberculosis and Yersinia enterocolitica gain access to the intestinal lymphatic system by traversing the M cell ... ... ... ... ... Subscribe to continue reading! ... ...

 

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