internalin B |
internalization peptides |
Complement factor C3b |
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Internalins constitute a family of genes associated with key virulence functions in the food-borne Gram-positive pathogen Listeria monocytogenes (Bierne et al, 2007; Dramsi et al, 1997; Engelbrecht et al, 1996). Listeria monocytogenes uses M cells as an entry point (MacDonald and Carter, 1980) or can enter intestinal cells (Racz et al, 1972).
The two best studied members of this family, for which cellular receptors have been identified, are encoded by the inl genetic locus, an operon encoding internalin A (abbr. inlA) and internalin B (abbr. inlB) (Gaillard et al, 1991). Both proteins function as an invasin that permits entry of the pathogen into a variety of different host cell types
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