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integrin-alpha-1

Approved gene symbol: ITGA1. In the nomenclature of CD antigens this protein has been given the designation CD49a.

The human gene encoding integrin-alpha-1 has been cloned by Briesewitz et al (1993). Integrin-alpha-1 usually occurs in association with integrin-beta-1. The heterodimeric protein is known also as VLA-1 [very late activation antigen 1] and acts as a receptor for laminin and collagen, promoting cell attachment and neurite outgrowth in neural cells and attachment in hematopoietic cells. Suzuki et al (2007) have demonstrated that semaphorin 7A stimulates cytokine production in monocytes ... ... ... ... ... Subscribe to continue reading! ... ...

 

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