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gallerimycin

The cDNA for this peptide, which resembles defensins, has been cloned from a hemocyte cDNA library established from greater wax moth, Galleria mellonella. The sequence shows similarities to the antifungal peptides drosomycin from Drosophila melanogaster and heliomicin from Heliothis virescens. Expression is upregulated after stimulation with bacterial lipopolyscaccharides. Gallerimycin is active against the entomopathogenic fungus Metarhizium anisopliae, but not against yeast, Gram-negative bacteria and Gram-positive bacteria (Schuhmann et al, 2003).

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