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gadd7

[growth arrest and DNA damage induced gene-7] This hamster gene belongs to the family of GADD genes the expression of which is induced by various genotoxic and non-genotoxic stresses (Hollander et al, 1996). gadd7 cDNA does not contain an appreciable open reading frame and does not appear to encode a protein product, but instead may function at the RNA level.

Expression of gadd7 has been found to be induced by alkylating agents, such as methyl methanesulfonate (MMS), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and mechlorethamine HCl (HN2), oxidizing agents, such as hydrogen peroxide, and growth arrest signals, such as medium starvation. Overexpression of gadd7 leads to a decrease in cell growth (Crawford et al, 1996.

Crawford et al (1996) have identified an RNA of 950 bases in hamster HA1 fibroblasts, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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