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endoG

[endonuclease G] aproved gene symbol: ENDOG. Endonuclease G is a mitochondrion-specific endonuclease that preferentially cleaves CG-rich DNA stretches (Tiranti et al, 1995). EndoG encodes a homolog of Caenorhabditis elegans CPS-6.

EndoG is activated specifically by stimuli eliciting cell death by apoptosis. The enzyme is released from mitochondria and translocates to the nucleus, causing the fragmentation of chromatin DNA. DNA fragmentation also occurs in fibroblasts of mice lacking DFF-45, another endonuclease involved in DNA fragmentation during apoptosis. Nucleosomal ... ... ... ... ... Subscribe to continue reading! ... ...

 

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