ectromelia poxvirus p13

This poxvirus protein (Mousepox virus p13) functions as a decoy receptor for IL18 (hence also: Ectromelia virus IL18BP [Ectromelia virus IL18 binding protein] (or Mousepox virus IL18BP [Mousepox virus IL18 binding protein]. It binds IL18 with high affinity and inhibits IL18 activities in vitro (Born et al, 2000). The equivalent gene in vaccinia virus is C12L.

Mice infected with a p13 deletion mutant of ectromelia virus had elevated cytotoxicity for YAC-1 tumor cell targets compared with control animals due to elevated locacl NK-cell functions Additionally, the p13 ... ... ... ...
 
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Entry last modified: January 2002