cyclophilin-18
This factor is released by Toxoplasma gondii. It is a potent stimulator of IL12 production by dendritic cells. The factor acts through one of the receptors for chemokines, CCR5 (Aliberti et al, 2003).
Cyclophilin-18 binds directly to human CCR5. MIP-1-beta and HIV1 R5 gp120 partially compete with this interaction. Cyclophilin-18 inhibits HIV1 cell fusion and infection with cell-free virus. Inhibition mediated by Cyclophilin-18 does not induce production of beta-Chemokines or cause CCR5 downmodulation (Golding et al, 2003).
Ibrahim et al (2009) have reported that cyclophilin-18 induces the production of nitric oxide, IL12, and TNF-alpha
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