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casein-alpha-s1(174-184)

also: alpha-s1-casein(174-184). This bioactive fragment of casein-alpha-s1 with the sequence TDAPSFSDIPN has been identified as a casein fermentation product of Raoultella ornithinolytica (formerly Klebsiella ornithinolytica) an aerobic Gram-negative bacterium in the family Enterobacteriaceae. It exists in the form of a complex with Tromethamine and has been shown to act as an anticancer peptide with cytotoxic and cytopathic effects in HeLa cells. It also causes cell death by apoptosis in HeLa cells but shows only minimal effecds in normal human skin fibroblasts (Fiołka MJ et al, 2015).

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