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WT1-pTj peptide

This peptide, KDCERRFSRSDQLKRHQRRHTGVKPFQ, is derived from the WT1 [Wilms tumor protein 1], a transcription factor that has been associated in malignant melanoma with cell survival and metastasis. The sequence corresponds to amino acids 349-375 of the human WT1 protein (WT1(349-375)).

This lysine-arginine rich peptide functions as a cell-penetrating peptide. Massaoka et al (2014) have reported that the peptide quickly penetrates human melanoma cells and induces senescence, enhances transcriptional activity of the p53 oncoprotein ... ... ... ... ... Subscribe to continue reading! ... ...

 

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