WECHE

(said to be an acronym derived from "weird chemokine") This factor was isolated from endothelial cell lines (derived from the AGM region; see also primitive hematopoiesis). The factor influences hematopoiesis and appears to regulates hematopoietic differentiation in different ways. It blocks the growth of yolk sac-derived endothelial cells and is chemotactic for bone marrow cells. WECHE inhibits the formation of erythroid cells without having any effects on myeloid or B-cell formation. WECHE represses the development of BFU-E from mouse fetal liver or bone marrow progenitor cells. The factor does not interfere with ... ... ... ...
 
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Entry last modified: January 2002