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WAH-1

[worm AIF homolog 1] The gene encoding this Caenorhabditis elegans protein is a worm ortholog of the apoptosis inducing factor AIFM1 [apoptosis inducing factor mitochondrion associated 1] (PDCD8; mutated in Harlequin mice), a human mitochondrial oxidoreductase that is released from mitochondria and induces chromosome condensation and fragmentation during cell death by apoptosis.

Reduction of WAH-1 gene expression in Caenorhabditis elegans has been shown to delay the normal progression of apoptosis and to enhance the defects of other cell death ... ... ... ... ... Subscribe to continue reading! ... ...

 

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