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VLA-6

[very late activation antigen 6] Very late activation antigens are a family of heterodimeric transmembrane proteins that belong to the integrin family of cell adhesion molecules (Hynes, 1987; Ruoslahti, 1991). These antigens consist of a distinct alpha subunit non-covalently linked to a common beta subunit. Their name refers to the observation that beta-chains increase in amount and additional alpha-subunits appear after long-term T-cell activation (Hemler et al, 1987).

VLA-6 is a heterodimeric protein complex identified on platelets. It consists of a distinct integrin-alpha-6 subunit and the integrin-beta-1 subunit that is also a constituent of other members of the family of VLA proteins (Hemler et al, 1988). Based on its identity with ... ... ... ... ... Subscribe to continue reading! ... ...

 

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