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[VLA-4(+), VLA-4(-), VLA-4(low), VLA-4(high), VLA-4(int)]

[very late activation antigen 4] Very late activation antigens are a family of heterodimeric transmembrane proteins that belong to the integrin family of cell adhesion molecules (Hynes, 1987; Ruoslahti, 1991). These antigens consist of a distinct alpha subunit non-covalently linked to a common beta subunit (ITGB1 [integrin-beta-1]). Their name refers to the observation that beta-chains increase in amount and additional alpha-subunits appear after long-term T-cell activation (Hemler et al, 1987).

Based on its identity with ITGA4 [integrin-alpha-4], VLA-4 is being referred to also as VLA-alpha 4 [ ... ... ... ... ... Subscribe to continue reading! ... ...


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