VLA2 receptor alpha 2 subunit |
VLA-3 receptor alpha 3 subunit |
lineage |
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[VLA-3(+), VLA-3(-), VLA-3(low), VLA-3(high), VLA-3(int)]
[very late activation antigen 3] Very late activation antigens are a family of heterodimeric transmembrane proteins that belong to the integrin family of cell adhesion molecules (Hynes, 1987; Ruoslahti, 1991). These antigens consist of a distinct alpha subunit non-covalently linked to a common beta subunit. Their name refers to the observation that beta-chains increase in amount and additional alpha-subunits appear after long-term T-cell activation (Hemler et al, 1987).
Based on its identity with ITGA3 [integrin-alpha-3], VLA-3 is being referred to also as VLA-alpha 3 [very late activation antigen alpha-3
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