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VCAM-1

[vascular cellular adhesion molecule 1; vascular cell adhesion protein 1] VCAM-1 has been identified and cloned as a previously undescribed adhesion molecule the expression of which is induced by cytokines on human endothelial cells (Osborn et al, 1989). The protein mediates binding lymphocytes. VCAM-1 mRNA is present in endothelial cells at 2 hr after treatment with IL1 or TNF-alpha and is maintained for at least 72 hr; leukocyte binding activity parallels mRNA induction. Cells transfected with VCAM-1 bind the human leukemia lines Jurkat, Ramos, Raji, ... ... ... ... ... Subscribe to continue reading! ... ...

 

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