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UNC40

[uncoordinated locomotion-40] This Caenorhabditis elegans gene has been implicated in guidance of circumferential migrations of pioneer axons and mesodermal cells on the nematode body wall. UNC40 is a homolog of the cell surface proteins DCC [Deleted in Colorectal Cancer] and neogenin. The protein is expressed on motile cells and pioneer neurons. UNC40 acts cell autonomously to orient movement toward UNC6 sources, which is a soluble axon guidance protein.

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Entry last modified: July 2003

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