Thrombostatin con-3 |
thrombotic thrombocytopenic purpura |
DystromiRs |
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Thrombostatin con-6 [ADAMTSL5(44-60)] [WTRCSSSCGRGVSVRSR] is a bioactive fragment (see also: cryptides) corresponding to positions 44-60 of ADAMTSL5 [ADAMTS-like-5], a gene that is known also as THSD6 [Thrombospondin type-1 domain-containing protein 6]. The ADAMTSL5 protein shows similarity to members of the ADAMTS protein family but lacks the metalloprotease and disintegrin-like domains which are typical of that family.
The peptide fragment has been shown to inhibit the proliferation and migration of human umbilical vein endothelial cells in vitro and is therefore thought to possess
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