ADAMTSL4 |
ADAMTSL6 |
LSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAH |
||
[ADAMTS-like-5] The ADAMTSL5 protein shows similarity to members of the ADAMTS protein family but lacks the metalloprotease and disintegrin-like domains which are typical of that family. In databanks the protein is known also as THSD6 [Thrombospondin type-1 domain-containing protein 6]. Bader et al (2012) have reported that alternative splicing of ADAMTSL5 at its 5' end generates two transcripts that encode different signal peptides, but the same mature protein. These transcripts differ in their translational efficiency. Recombinant ADAMTSL5 is a secreted, N-glycosylated 60 kDa glycoprotein located in the subcellular matrix, on the cell surface, and in the medium of transfected cells. The protein is expressed broadly in adult
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