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ADAMTS protein family

[ADAMTS family]

ADAMTS proteins are structurally related to ADAM protein family in that they contain a disintegrin and a metalloprotease domain. A collective term for members of this protein family is metallospondins. ADAMTS proteins lack the EGF-like domain found normally in members of the ADAM protein family. They also do not possess the canonical disintegrin sequence found in the ADAM protein family (Tang and Hong, 1999; Porter et al, 2005; Apte, 2009).

In addition, ADAMTS proteins also contain varying numbers of a thrombospondin type 1 motif. ADAMTS proteins contain a signal sequence and are secreted rather than membrane bound proteins.

Members of this family include

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