TSC403

This designation refers to a human lung-specific gene identified by Ozaki et al (1998). The TSC cDNA encodes a protein of 416 amino acids with significant similarities to lysosome-associated membrane glycoproteins LAMP-1 and LAMP-2. The gene localizes to chromosomal band 3q27, a genomic region that is often amplified in human cancers of several tissue types. High levels of TSC403 transcripts are found primary cancers of the esophagus, colon, fallopian tube, ovary, breast, and liver, although expression of this gene is barely detectable in corresponding normal tissues. The TSC403 gene encodes a protein now named LAMP-3.

In the nomenclature of CD antigens this protein has been given the designation CD208.

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