TSC22 domain family member 1 |
TSC403 |
Actinobacillus actinomycetemcomitans Cytolethal distending toxin |
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[TGF-beta-stimulated clone-36] This gene has been identified, together with several others, by virtue of its overexpression following treatment of mouse osteoblastic MC3T3-E1 cells with TGF-beta. The gene encodes a protein of 35 kDa that is detected also in the conditioned medium of these cells. The amino acid sequence has some similarity with follistatin, a binding protein for Activin A (Shibanuma et al, 1993). Expression of TSC-36 is decreased dramatically in v-Ki-ras-transformed MC3T3 cells or in transformed NIH 3T3 cells (DT), while it is expressed at normal levels in a flat revertant (C11). The protein has been identified independently in conditioned medium of
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