TMEM4 |
TMEM45A |
Naegleria pore-forming protein |
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[transmembrane protein 14A] A databank synonym is C6orf73 [chromosome 6 open reading frame 73].
Woo et al (2011) have identified TMEM14A as a mitochondria-associated membrane protein containing a putative transmembrane domain.
The protein plays a role in cell death by apoptosis, functioning as a suppressor of BAX. Over-expression of TMEM14A in U87MG cells inhibits apoptosis induced by N-(4-hydroxyphenyl)retinamide. TMEM14A prevents loss of mitochondrial membrane potential, the release of cytochrome C, and the activation of caspase-3, but not the generation of reactive oxygen species
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