thanatos-associated protein domain |
THAP0 |
HHV-8 GPCR |
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[TNF homolog activating apoptosis nuclear factor-kappaB c-Jun NH2-terminal kinase] THANK is a type 2 transmembrane protein that belongs to the TNF family or proteins. In the nomenclature of CD antigens this protein has been given the designation CD257. Another designation is TNFSF13B [TNF ligand superfamily member 13B].
THANK mRNA is expressed at high levels by peripheral blood leukocytes, lymph node, spleen, thymus, and also by a variety of hematopoietic cell lines. Treatment of human myeloid U937 cells with purified THANK activates nuclear transcription factor NF-kappa-B
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