TCF-8

[transcription factor 8] This human gene on chromosome 10p12 encodes a zinc finger protein, designated, Nil-2-a, which inhibits IL2 gene expression in T-lymphocytes by binding to a negative regulatory domain 100 nucleotides 5' of the IL2 transcription start site (Williams et al, 1991, 1992). The factor is being referred to also as T-lymphocyte-specific interleukin-2 inhibitor.

TCF-8 has been identified independently as AREB6 and delta-EF1. It is being referred to also as Zfhx1a [Zinc finger homeobox protein 1a] or Zfhep [ ... ... ... ...
 
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Entry last modified: April 2014