TBK1

[TANK-binding kinase-1; TRAF family member-associated NF-kappa-B activator binding kinase] The name refers to the observation that TBK1 associates with the adaptor protein TANK [TRAF family member-associated NF-kappa-B activator]. The cDNA encoding TBK1 has been cloned by Pomerantz JL and Baltimore D (1999) who reported that it is part of a protein complex that activates transcription factor NF-kappa-B activity. TBK1 has been identified independently as NAK [NF-kappa-B-activating kinase] by Tojima Y et al (2000) who reported that the enzyme plays a role in NF-kappa-B signalling by activating I-kappa-B ... ... ... ...
 
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Entry last modified: April 2022