SIGLEC-8
[sialic acid binding immunoglobulin-like lectin 8] This protein is a member of a family of type 1 transmembrane proteins. They are cell surface lectins that have the ability to bind to sialic acids and mediate interactions between proteins and carbohydrates (see also: SIGLECs). Several studies describing the sialoside specificities of individual SIGLECs have been reported (Blixt et al, 2003; Rapoport et al, 2006).
The SIGLEC-8 protein (431 amino acids) has homology with other sialoadhesin family members (CD33 and SIGLEC-5) (Kikly et al, 2000). A longer form of SIGLEC-8, termed SIGLEC-8L (SIGLEC-8-long) has been identified by Foussias et al (2000).
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