SIGLECs

[sialic acid binding immunoglobulin-like lectin] SIGLECs constitute a family of cell surface lectins that act as receptors for glycoprotein and glycolipid ligands containing sialic acid. Several studies describing the sialoside specificities of individual SIGLECs have been reported (Blixt et al, 2003; Rapoport et al, 2006). For an overview of SIGLECs and their ligands see: Gonzalez-Gil A and Schnaar (2021)

These proteins are type 1 transmembrane proteins with at least one extracellular immunoglobulin-like domains (Varki and Angata, 2006). Many of the SIGLECs are expressed on overlapping subsets of immune system cells.

An evolutionarily conserved subgroup of SIGLECs comprises SIGLEC-1, SIGLEC-2, and SIGLEC-4 ... ... ... ...
 
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Entry last modified: June 2021