SIGLEC-5

[sialic acid binding immunoglobulin-like lectin 5] This protein is a member of a family of type 1 transmembrane proteins. They are cell surface lectins that have the ability to bind to sialic acids and mediate interactions between proteins and carbohydrates (see also: SIGLECs). Several studies describing the sialoside specificities of individual SIGLECs have been reported (Blixt et al, 2003; Rapoport et al, 2006).

SIGLEC-5 (551 amino acids) has been identified by Cornish et al (1998). It has been identified independently as Ob binding protein 2 (OBBP2) by Patel et al (1999) who also observed weak binding to leptin. The protein is related to CD33 and has been termed CD33L2 [ ... ... ... ...
 
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Entry last modified: February 2005