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[Serum-free mouse embryo] This neural stem cell line was derived from 16 day old BALB/c mouse embryos grown in a basal nutrient medium supplemented with insulin, transferrin, EGF, high-density lipoprotein (HDL), and fibronectin (Loo et al, 1989). These cells do not cause tumors in nude mice. They do not show signs of senescence and show no gross karyotype anomalies (Loo et al, 1987).
SFME cells represent neural progenitor cells, which differentiate into functional astrocytes upon exposure to TGF-beta or serum (Loo et al, 1995). TGF-beta
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