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RTK6

[receptor tyrosine kinase 6] This protein receptor tyrosine kinase has been isolated from a complementary DNA library of SKOV-3, an epithelial ovarian cancer cell line, by Laval et al (1994). The transcript is expressed at low levels in heart, placenta, lung, liver, muscle, kidney, and pancreas, with high levels of expression in the brain. In situ hybridization analysis localizes the mRNA in epithelial cells of the ovary, kidney, small bowel, lung, thymus, and brain.

Sequence analysis shows that this kinase is identical with DDR [discoidin domain receptor], which was renamed DDR1 [discoidin domain receptor 1] following identification of the related DDR [ ... ... ... ... ... Subscribe to continue reading! ... ...

 

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