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RRV IL6

[rhesus macaque rhadinovirus IL6; abbr. also RvIL6] This viral homolog of IL6 is encoded in the genome of rhesus macaque rhadinovirus (RRV), a gamma-2 herpesvirus that is related to but distinct from the KSHV [Kaposi sarcoma-associated herpesvirus] (Desrosiers et al, 1997), which also encoded viral IL6.

RRV IL6 supports cell proliferation in a bioassay using factor-dependent cell line. There are indications that RRV IL6 does not inhibit but may instead potentiate normal cellular IL6 signaling to B-cells (Kaleeba et al, 1999).

Orzechowska BU et al (2009) have reported that this viral IL6 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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