RLRLLTLQSWLL |
RLVG |
apoptotic chromatin condensation inducer 1 |
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[RIG-I-like receptors; retinoic acid inducible gene-I-like receptors] These receptors comprise RIG-I, MDA-5, and LGP2 and function as pattern recognition receptors in the cytoplasm that initiate innate immune responses against RNA virus infections and also processed self RNAs (Szabo and Rajnavolgyi, 2013; Zinzula and Tramontano, 2013; Schlee M, 2013). RLRs have been shown to be conserved in vertebrates (Zou et al, 2009).
RLRs are RNA helicases but differ in their domain structures (RIG-I and MDA-5 contain a CARD domain; LGP2 does not). The proteins cooperate in signaling cross-talk networks with
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