MDA1 |
MDA-7 |
associative neurons |
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[melanoma differentiation-associated gene 5] The expression of the gene encoding MDA-5, a protein that contains a characteristic DEAD box motif, is upregulated in HO-1 human melanoma cells induced to terminally differentiate (Kang et al, 2004). The protein contains a CARD domain and an RNA helicase domain. Expression of the gene is upregulated by treatment of melanoma cells or fibroblasts with IFN-beta (Kang et al, 2002, 2004). Expression in HO-1 cells reduces colony formation in a colony formation assay and induces cell death by apoptosis.
MDA-5 is being referred to also as
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