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RIP3

[receptor interacting protein-3] The approved gene symbol is RIPK3 [receptor-interacting serine/threonine kinase 3].

The N-terminal kinase domain of RIP3 shares homology with the kinase domains of RIP and RIP2 (Yu et al, 1999; Sun et al, 1999). The carboxy-terminal domain of RIP3 is unique and does not share significant sequence homology to the death domain of RIP, the CARD domain of RIP2, or any other apoptosis-inducing domain. The human RIP3 gene maps to chromosome 14q11.2 (Kasof et al, 2000).

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