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Polybia-CP

This inflammatory peptide (ILGTILGLLKSL), related to mastoparan, has been isolated from the venom of the social wasp Polybia paulista (Souza et al, 2005). Polybia-CP is chemotactic for polymorphonucleated leukocytes is active against Gram-positive bacteria, but does not cause hemolysis of rat erythrocytes and does not possess mast cell degranulation activity.

Wang et al (2016) have reported that polybia-CP has potent antifungal activity and fungicidal activity against Candidian species. It is membrane-active action and increases cellular reactive oxygen species production.

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Entry last modified: March 2016



 
 
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