Degranulation

This term describes the massive release of preformed cytoplasmic secretory vesicles (so-called granules) and their contents by certain cell types. Degranulation occurs in response to external signals and is regulated by various activating and inhibitory receptors. Granules contain a plethora of low-molecular weight mediators as well as cytokines, growth factors, chemokines, peptides, hormones, neuropeptides, enzymes, or antimicrobial peptides which are released during degranulation. The degranulation process is usually fast and an 'all-at-once'-reaction, and cells recover from this process.

Granule contents vary between cell types ... ... ... ...
 
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Entry last modified: November 2019