Oxyntomodulin
abbr. OXY, or OXM. Oxyntomodulin is a gut hormone that regulates digestion. The name derives from the observation that this hormone is approximately 20 times more potent than glucagon on oxyntic cells (Bataille et al, 1981, 1982). The hormone is found also in the central nervous system (Blache et al, 1988).
Oxyntomodulin is obtained by proteolytic processing of the glucagon precursor and corresponds to amino acids 30-69 of preproglucagon. This process may involve various prohormone convertases. Zhu et al (2003) have identified oxytnomodulin as an in vivo substrate of dipeptidyl peptidase 4 (CD26). Oxyntomodulin (
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