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OSCAR

approved gene symbol; [osteoclast-associated receptor] also: osteoclast-associated immunoglobulin-like receptor. A databank synonym is PIgR3 [Polymeric immunoglobulin receptor 3; Poly-Ig receptor 3].

The cDNA for the murine and human receptor (263 amino acids, 73 % identity) has been cloned by Kim et al (2002). The receptor contains 2 extracellular immunoglobulin-like domains. This receptor is expressed specifically on osteoclast lineage cells and regulates osteoclastogenesis (Kim et al, 2002). Murine macrophages ... ... ... ... ... Subscribe to continue reading! ... ...

 

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